Using exoskeletons in physical therapy can help improve gait quality, muscle strength, and cognitive ability.
- Improved Gait Quality
In a study involving ten patients with MS, conducted by Kessler Foundation, patients were rehabilitated using an Ekso Bionics exoskeleton, and their recovery progress was compared to participants who used conventional gait training methods. The outcomes studied in this case were walking endurance, functional mobility, brain connectivity, and cognitive processing speed. After four weeks, the patients who used the exoskeleton were shown to have outperformed those who used conventional gait training methods. Additionally, these results were also corroborated by MRI brain scans. 
In a 2021 randomized controlled trial investigating how exoskeletons affect gait speed and functional mobility in individuals with multiple sclerosis (MS), the researchers concluded that exoskeletons could help preserve gait speed and improve functional mobility. 
- Increased Exercise Intensity
Over-exertion is a big concern for people with MS because it contributes to the progression of the disease. The question then becomes, how can patients train without overexerting themselves? Another part of this puzzle is attending to patients who might not be able to achieve the required intensity in their exercise program. According to Brian M. Sandroff, Ph.D., lead investigator and a Senior Research Scientist at the Kessler Foundation’s Exercise Neurorehabilitation Research Laboratory, “One of the big problems is that people with MS who have a severe disability status in terms of walking might not be able to exercise at a sufficient intensity to elicit benefits.” 
Exoskeletons offer the solution in these two instances as they can help patients train intensely without over-exertion, as evidenced in a 2021 study.  They can also help patients with severe mobility disabilities to attain the required intensity for their progress. An exoskeleton like EksoNR allows physical therapists to customize the steps in each session, thereby reducing the possibility of over-exertion.
- Improved Muscle Strength
Exoskeletons are extremely helpful and can help patients with different degrees of injury increase their muscle strength. They can also help patients with leg weakness to stand, walk, squat, and perform other movements. In a 2015 study of patients with spinal cord injuries, patients were shown to achieve walk times ranging from 28 to 94 minutes, with some averaging a speed of up to 0.21m/s. 
- Improved Cognitive and Emotional State
Exoskeleton benefits go beyond physical improvements. They also affect a patient’s mental abilities. The direct involvement required from patients during the rehabilitation period can produce a psychological effect. Some exoskeletons like EksoNR keep track of a patient’s progress, and showing patients positive progress reports can help improve their hope and boost their morale.